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Tesofensine is a novel compound that acts as a triple reuptake inhibitor, targeting the neurotransmitters serotonin, norepinephrine, and dopamine. Primarily researched for its potential in weight management, it has shown promise in promoting weight loss by increasing energy expenditure and reducing appetite. Tesofensine may also play a role in improving metabolic health and managing conditions related to obesity. Ongoing studies are focused on its efficacy, safety profile, and mechanisms of action, making it a subject of interest in obesity research and metabolic studies.