TB-500 5MG NASAL SPRAY

TB-500 (Thymosin Beta-4) is a synthetic version of a naturally occurring thymosin β4 peptide, which has been widely studied for its potential role in cellular regeneration, wound healing, and angiogenesis. Researchers have explored TB-500’s effects on tissue repair, inflammation modulation, and neuroprotective mechanisms in preclinical studies.

Please note: Our nasal sprays do not come reconstituted due to the fragile nature of peptides and the potential for degradation. Water for reconstitution may be purchased online with us or on Amazon. Our nasal spray labels show "10ML", which is the amount of water your lab tech should use to reach the dosage indicated on the label.

TB-500 & Nasal Administration in Research

Recent research has investigated the feasibility of intranasal TB-500 delivery as a non-invasive method of administration. Potential research advantages of nasal spray application include:

• Bypassing first-pass metabolism, leading to higher systemic absorption
• Potential neuroprotective effects via the olfactory and trigeminal pathways
• Rapid uptake and circulation, potentially allowing for efficient systemic research applications

While subcutaneous and intravenous routes are traditionally studied, nasal delivery is emerging as a potential research method for systemic and neurological pathways.

Mechanism of Action & Research Applications

TB-500 has been researched for its ability to modulate actin, a key protein involved in cell migration, tissue growth, and wound repair. Preclinical studies suggest it may play a role in:

✔ Wound Healing & Tissue Regeneration – Studies indicate it may stimulate angiogenesis (blood vessel growth) and cell migration.
✔ Muscle & Tendon Recovery – Research suggests it may assist in reducing fibrosis and promoting tissue remodeling.
✔ Neuroprotective Effects – Some studies explore its influence on cognitive function, nerve repair, and neuroinflammation.
✔ Anti-Inflammatory Potential – Preclinical models suggest it may help modulate cytokine activity and oxidative stress.
✔ Cardiovascular Research – Studies suggest it may play a role in cardiac tissue repair and vascular function.

Molecular & Structural Information

• Molecular Formula: C212H350N56O78S
• Molecular Weight: 4963.5 g/mol
• Sequence: Ac-Ser-Asp-Lys-Pro-Asp-Met-Ala-Glu-Ile-Glu-Lys-Phe-Ala-Glu-Asp-Gly-Gln-Ser-Gly-Glu-Gly-Glu-Thr-Gln-Glu-Lys-Glu-Ser

Storage & Stability

• Store at -20°C for long-term stability
• Keep in a light-protected, cool environment
• Reconstitute with research-grade solvents

Legal & Research Disclaimer

TB-500 is for research purposes only. It is not for human consumption, medical use, or diagnostic applications. All information is provided for scientific and educational research.