PT-141 10MG

PT-141, also known as Bremelanotide, is a synthetic melanocortin receptor agonist derived from Melanotan II (MT-II). It has been widely studied for its potential effects on melanocortin receptors (MC1R-MC5R), particularly in research involving sexual function, neurological responses, and vasodilation studies. Unlike PDE5 inhibitors that target blood flow, PT-141 is believed to act on the central nervous system (CNS), influencing dopaminergic pathways related to arousal and motivation.

Please note: Our nasal sprays do not come reconstituted due to the fragile nature of peptides and the potential for degradation. Water for reconstitution may be purchased online with us or on Amazon. Our nasal spray labels show "10ML", which is the amount of water your lab tech should use to reach the dosage indicated on the label.

PT-141 & Nasal Administration

Nasal delivery is a preferred research method for PT-141 due to its ability to:

• Bypass first-pass metabolism, increasing bioavailability
• Rapidly enter the bloodstream, leading to quicker systemic absorption
• Directly influence the brain via the olfactory and trigeminal pathways

Several studies suggest that intranasal administration may provide efficient systemic uptake, making it a viable route for investigating PT-141’s neurological and physiological effects.

Mechanism of Action

PT-141 is believed to work by:

• Activating melanocortin receptors (MC3R and MC4R) in the hypothalamus, which may play a role in arousal research
• Interacting with dopaminergic pathways, potentially influencing mood, motivation, and reward responses
• Inducing vasodilation, leading to increased blood flow, which is of interest in vascular and circulation studies
• Bypassing the nitric oxide pathway, differentiating it from traditional PDE5 inhibitors in research

Potential Research Applications

PT-141 is currently being explored in preclinical and clinical research related to:

• Neuroendocrine Studies – Examining its effects on melanocortin receptor activation and hormone regulation
• Arousal & Motivation Research – Investigating its impact on dopamine and CNS-related arousal pathways
• Vasodilation & Circulation Studies – Assessing its role in blood flow modulation
• Melanocortin & Neurological Research – Exploring its influence on neurotransmitter function and cognitive processes

Molecular & Structural Information

• Peptide Name: PT-141 (Bremelanotide)
• Molecular Formula: C50H68N14O10
• Molecular Weight: 1025.2 g/mol
• Sequence: Ac-Nle-c[Asp-His-D-Phe-Arg-Trp-Lys]-OH

Storage & Stability

• Recommended Storage: Store at -20°C for long-term stability
• Handling: Reconstitute with sterile bacteriostatic water or research-grade solvent
• Shelf Life: Maintain in light-protected, cool environments

Legal & Research Disclaimer

PT-141 is intended for research purposes only. It is not for human consumption, medical use, or diagnostic applications. All information provided is for scientific and educational research.