PT-141 10MG

PT-141, also known as Bremelanotide, is a synthetic melanocortin receptor agonist derived from Melanotan II (MT-II). It has been widely studied for its potential effects on melanocortin receptors (MC1R-MC5R), particularly in research involving sexual function, neurological responses, and vasodilation studies. Unlike PDE5 inhibitors that target blood flow, PT-141 is believed to act on the central nervous system (CNS), influencing dopaminergic pathways related to arousal and motivation.

PT-141 & Nasal Administration

Nasal delivery is a preferred research method for PT-141 due to its ability to:

• Bypass first-pass metabolism, increasing bioavailability
• Rapidly enter the bloodstream, leading to quicker systemic absorption
• Directly influence the brain via the olfactory and trigeminal pathways

Several studies suggest that intranasal administration may provide efficient systemic uptake, making it a viable route for investigating PT-141’s neurological and physiological effects.

Mechanism of Action

PT-141 is believed to work by:

• Activating melanocortin receptors (MC3R and MC4R) in the hypothalamus, which may play a role in arousal research
• Interacting with dopaminergic pathways, potentially influencing mood, motivation, and reward responses
• Inducing vasodilation, leading to increased blood flow, which is of interest in vascular and circulation studies
• Bypassing the nitric oxide pathway, differentiating it from traditional PDE5 inhibitors in research

Potential Research Applications

PT-141 is currently being explored in preclinical and clinical research related to:

• Neuroendocrine Studies – Examining its effects on melanocortin receptor activation and hormone regulation
• Arousal & Motivation Research – Investigating its impact on dopamine and CNS-related arousal pathways
• Vasodilation & Circulation Studies – Assessing its role in blood flow modulation
• Melanocortin & Neurological Research – Exploring its influence on neurotransmitter function and cognitive processes

Molecular & Structural Information

• Peptide Name: PT-141 (Bremelanotide)
• Molecular Formula: C50H68N14O10
• Molecular Weight: 1025.2 g/mol
• Sequence: Ac-Nle-c[Asp-His-D-Phe-Arg-Trp-Lys]-OH

Storage & Stability

• Recommended Storage: Store at -20°C for long-term stability
• Handling: Reconstitute with sterile bacteriostatic water or research-grade solvent
• Shelf Life: Maintain in light-protected, cool environments

Legal & Research Disclaimer

PT-141 is intended for research purposes only. It is not for human consumption, medical use, or diagnostic applications. All information provided is for scientific and educational research.