AOD-9604 2MG

AOD-9604 is a synthetic modified fragment of human growth hormone (hGH), specifically designed for lipolytic (fat metabolism) research. Originally studied for its potential role in obesity-related research, AOD-9604 has been investigated for its ability to stimulate fat breakdown (lipolysis) while reducing fat accumulation (lipogenesis).

Unlike full-length hGH, AOD-9604 does not stimulate IGF-1 levels, making it an area of interest in metabolic and weight-regulation research. Studies suggest that this peptide may be a useful tool in examining fat metabolism, energy expenditure, and potential regenerative properties.

Please note: Our nasal sprays do not come reconstituted due to the fragile nature of peptides and the potential for degradation. Water for reconstitution may be purchased online with us or on Amazon. Our nasal spray labels show "10ML", which is the amount of water your lab tech should use to reach the dosage indicated on the label.

AOD-9604 & Nasal Administration

While most AOD-9604 studies focus on subcutaneous injection, emerging data suggests that intranasal administration may offer a viable alternative for peptide absorption. Nasal delivery of peptides has been explored in various research models due to its potential for:

• Bypassing first-pass metabolism for direct absorption into the bloodstream
• Rapid bioavailability through the nasal mucosa
• Alternative routes of peptide uptake for pharmacokinetic studies

Although AOD-9604 nasal delivery has not been as extensively studied as injection-based methods, other peptides have demonstrated promising absorption rates via this route. Further clinical and preclinical research is needed to establish bioavailability, stability, and efficacy when administered nasally.

Mechanism of Action

AOD-9604 is a C-terminal fragment of hGH (amino acids 176-191) and retains the ability to activate beta-3 adrenergic receptors, which are involved in fat oxidation and thermogenesis. Research suggests that this peptide:

• Promotes lipolysis by triggering the breakdown of stored fat
• Inhibits lipogenesis, reducing the formation of new fat deposits
• May influence metabolic pathways associated with energy expenditure
• Does not activate IGF-1 receptors, differentiating it from full-length growth hormone

Potential Research Applications

AOD-9604 is currently being examined in various preclinical and clinical studies related to:

• Adipose Tissue Metabolism – Investigating mechanisms of fat oxidation and energy regulation
• Obesity Research – Examining its role in weight-related metabolic studies
• Cartilage & Joint Research – Some studies suggest possible applications in cartilage and tissue regeneration
• Peptide Bioavailability Research – Exploring alternative administration routes, including nasal absorption

Molecular & Structural Information

• Peptide Name: AOD-9604 (hGH Fragment 176-191)
• Molecular Formula: C78H123N23O23S2
• Molecular Weight: 1815.08 g/mol
• Sequence: Tyr-Leu-Arg-Ile-Val-Gln-Cys-Arg-Ser-Val-Glu-Gly-Ser-Cys-Gly-Phe

Storage & Stability

• Recommended Storage: Keep at -20°C for long-term stability
• Handling: Reconstitute using sterile bacteriostatic water or research-grade solvent
• Shelf Life: Stability studies suggest viability under proper storage conditions

Legal & Research Disclaimer

AOD-9604 is intended for research purposes only. It is not for human consumption, medical use, or diagnostic applications. All information presented is for scientific and educational research.